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KMID : 1123920060200030675
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Korean Journal of Oriental Physiology and Pathology
2006 Volume.20 No. 3 p.675 ~ p.679
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Effect of Thesium Chinense Turczaninow on Breast Cancer Chemopreventive enzyme activity in In vitro
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Shon Yun-Hee
Kim Mee-Kyung
Park Sun-Dong
Nam Kyung-Soo
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Abstract
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The effect of water extract from Thesium chinese Turczaninow (TCTW) on proliferation of human breast cancer cells, nitric oxide production, nitric oxide synthase expression, and ornithine decarboxylase activity was tested. TCTW inhibited the growth of both estrogen-independent MDA-MB-231 and estrogen-dependent MCF-7 human breast cancer cells. Lipopolysaccharide-induced nitric oxide (NO) production was significantly reduced by TCTW at the concentrations of 1.0 (p<0.05) and 5.0 mg/ml (p<0.005). Expression of inducible nitric oxide synthase (iNOS) was also suppressed with the treatment of TCTW in Western blot analysis. TCTW inhibited induction of ornithine decarboxylase by 12-O-tetradecanoylphorbol-13-acetate (TPA), a key enzyme of polyamine biosynthesis, which is enhanced in tumor promotion. Therefore, TCTW is worth further investigation with respect to breast cancer chernoprevention or therapy.
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KEYWORD
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Thesium chinense Turczannow, nitric oxide, nitric oxide synthase, ornithine decarboxylase, breast cancer, chernoprevention
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